Literature references 2005- Immunotechnology

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the tumor lesion express CD137, and their activation by anti-CD137 mAb Aug 15, 2007 CD134 is expressed early after CD4 T cell activation and mediates for the congenic marker (CD45.1+ for WT OT-I or CD45.2+ for CD137−/−  Oct 24, 2017 Bystander activation had minimal effect on AIM markers. However, some T regulatory cells upregulate CD25 upon antigen stimulation. Upon lymphoid, myeloid cells and neutrophil activation, CD97 is upregulated to the interaction between CD97 and its ligand CD55 regulates T-cell activation  4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor superfamily member and has been designated TNFRSF9. Mouse 4 -  In this study, the SARS-CoV-2 specific T cell activation was studied by using a and CD137 fluorescent marked antibodies to detect potential antibody markers  Moreover, mHLA-DR was shown to be inversely related to markers of inflammation. activation is recognition by the T cell antigen receptor (TCR) of the class II MHC– peptide complex.

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Mouse 4 -  In this study, the SARS-CoV-2 specific T cell activation was studied by using a and CD137 fluorescent marked antibodies to detect potential antibody markers  Moreover, mHLA-DR was shown to be inversely related to markers of inflammation. activation is recognition by the T cell antigen receptor (TCR) of the class II MHC– peptide complex. CXCL16 and CD137 in Atherosclerosis. 6. Jatta, Ken  45 In Vitro Activation and Transduction of Nave CD8 + T Cells Yields a Larg e by lymphocytic infiltration and synchronized elevation of activation markers in the After sorting, cells were re stimulated using CD3/CD28/CD137 dynabeads  Markers of immunological memory, activation, and proliferation were examined by flow cytometry and immunohistochemistry, and the host-derived cytotoxic  A CD137 agonist increased vascular T cell infiltration and immune activation in mRNA levels correlated with markers for T cell activation and infiltration and  Led multiple projects, including the identification of novel surface markers in Neural reflexes regulate inflammation and electrical activation of the vagus CD137 promotes atherosclerosis and vascular inflammation in experimental models.

Type 1 Interferons Promote a Diabetogenic Microenvironment

CD137 (TNFSFR9) was originally identified as a molecule induced on the surface of activated mouse and human CD4+ and CD8+ T cells, with its expression undetectable on non-activated T cells. It is also found on both NK and dendritic cells. Detection and isolation of viable alloreactive T cells at the single-cell level requires a cell surface marker induced specifically upon T cell receptor activation. In this study, a member of the tumour necrosis factor receptor (TNFR)-family, CD137 (4-1BB) was investigated for its potential to identify the total pool of circulating alloreactive T cells.

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CD137 is a member of the TNFR-family with costimulatory function. Here we show that it also has many favorable characteristics as a surrogate marker for antigen-specific activation of human CD8 + T cells. In this issue of Clinical Cancer Research, Ye and colleagues use CD137 as a marker to successfully enrich and expand tumor-specific T cells from cancer tissues for adaptive immunotherapy (1). Adoptive cell therapy (ACT) has been very effective in the clinical treatment of advanced melanoma. Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. CD137 is a costimulatory receptor belonging to the TNF receptor superfamily and is almost uniformly expressed by activated CD4 + and CD8 + T cells as well as some APCs. 32 The inducible expression of CD137 in T cells upon activation has recently been used as a positive selection marker for immunomagnetic column selection for ex vivo expansion CD137 Can Act as a Surrogate Marker for T Cell Activation.

This panel contains 5 recombinant rabbit monoclonal antibodies against CD137 has been described to be a suitable marker for antigen-specific activation of human CD8 T cells, as CD137 is not expressed on resting CD8 T cells and its expression is reliably induced after 24 hours of stimulation. Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. CD137 has also been evaluated as a target molecule to selectively deplete alloreactive T cells in vitro [147]. Compared with other activation-induced antigens, CD137 showed a superior performance based on a consistently low baseline expression and a rapid upregulation following alloantigen stimulation. Se hela listan på frontiersin.org 2017-10-24 · PD-L1 is an activation-induced cell marker in humans and has been successfully used in conjunction with OX40 or CD25 to identify antigen-specific cells (Fig 4E, see ). When the co-upregulation of combinations of OX40, CD25, and PD-L1 were compared after tetanus peptide stimulation, we found that OX40 and CD25 expression detected the largest population of activated cells.
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Adoptive cell therapy (ACT) has been very effective in clinical CD137 is a costimulatory receptor belonging to the TNF receptor superfamily and is almost uniformly expressed by activated CD4 + and CD8 + T cells as well as some APCs. 32 The inducible expression of CD137 in T cells upon activation has recently been used as a positive selection marker for immunomagnetic column selection for ex vivo expansion of antigen‐specific T cells. 33, 34 The time to maximal CD137 expression on T cells following exposure to immunogen has been reported to vary from 12 cells expressing the activation marker CD137 (4-1BB) after exposure to overlapping PRAME peptides as a rapid method of ex vivo expansion for clinical use (Figure 1). CD137 is a costimulatory molecule and a member of the tumor necrosis factor receptor (TNFR) family. Transient increased expression is seen on cells that have been After 16 h, activated cells expressing CD137 were isolated with immunomagnetic beads and cocultured with irradiated CD137 neg fraction in medium supplemented with interleukin (IL)-2, IL-7 and IL-15.

In addition, perfusion was assessed with indirect markers, gases were measured The trending ability was good with a concordance Activation of CD137  The fibrinolytic enzyme system : new markers of potential interest in Acute pancreatitis : studies on smoking and protease activation /. Björn Lindqvist. CXCL16 and CD137 in atherosclerosis / Dick Wågsäter.
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Bengt Johansson Lindbom - Research Outputs - Lund University

In addition, the intracellular signaling domain of CD137 is crucial as a component of PDF | Objective Adoptive immunotherapy with ex vivo expanded tumor‐specific T cells has potential as anticancer therapy.

Molecular mechanisms in vascular inflammation - AVHANDLINGAR.SE

However, CD137 is also expressed in a number of other immune cells like B cells, dendritic cells, and monocytes, which hampers the isolation of antigen-specific T cells based solely on this marker.

With regard to T H 17 cells, their differentiation is under control TGF-β and IL-6-induced differentiation, IL-21-induced activation, and IL-23-regulated stabilization [15, 16]. As to iTregs, FOXP3 was found to an important marker of natural CD4 + CD25 + regulatory T cells. IFN- , IL-6, IL-8, IL-12), and activation markers (ICAM-1), and secretion of the anti-inflammatory cytokine IL-10 is reduced [12–14].